Therapeutic Sciences Graduate Program

My work focuses on understanding the structure and function of mutations within the hnRNPA2 RNA binding proteins that have been demonstrated to cause the formation of insoluble fibrils associated with a number of neurodegenerative diseases. This work will provide a better understanding of how RNA regulates hnRNPA2 granule assembly, and could also provide the basis for rational design of nucleic acid-based drugs that disrupt disease-causing hnRNPA2 mutants.