Theresa Raimondo
Biography
The overarching goal of my research program is to develop nanomedicine technologies for targeted therapeutic delivery, with a specific emphasis on RNA delivery to immune cells. Ongoing work is focused on investigating how RNA modifications regulate immune activation in health and disease, and exploring the mechanisms and design principles underlying efficient non-viral RNA delivery to targeted cells in vivo. We incorporate high-throughput techniques, and statistical (design of experiment) methodology to optimize RNA-nanoparticle design, with a particular focus on lipid nanoparticle optimization. Ultimately, our goal is to apply this fundamental knowledge to optimize the design of novel RNA-based immunotherapies for divergent therapeutic applications: cancer and tissue regeneration.