As a member of the Dr. Kate O’Connor-Giles’ laboratory at Brown, Jennifer Dumouchel focused her research on how precise and dynamic regulation of protein expression is required for neural development and function. The OCG lab is interested in how synapses form and function. The lab uses genetic, imaging, genomic and biochemical approaches in Drosophila to identify and characterize new conserved synaptic genes. During protein synthesis, mRNA is decoded by transfer RNAs (tRNAs) that are extensively post-transcriptionally modified to promote structural stability and accurate decoding. While a growing number of rare neurodevelopmental disorders linked to tRNA modifying enzymes have been reported, the effect of their disruption on nervous system development and function are poorly understood. Jennifer’s work helped identify putative tRNA methyltransferase 9B as a negative regulator of synaptic growth and function. Jennifer also studied the role of tRNA methyltransferase 1, which has recently been linked to intellectual disability, and found it functions in ensheathing glia to promote synapse formation and memory.

On May, 27th, 2025 Jennifer successfully defended her PhD thesis entitled “Role of tRNA methyltransferases in nervous system development and function.” Afterward, Jennifer enjoyed a celebration on campus with her Advisor, Dr. Kate O'Connor-Giles, and Brown students, faculty and staff. Jennifer’s family and friends also traveled to Brown as well so they could proudly celebrate this tremendous milestone in her life. Congratulations, Dr. Dumouchel!